gender differences

Influence of gender differences in the activity of medicines.

Influence of gender differences in the activity of medicines....

The excretion of drugs is depending of three factors: the glomerular filtration rate (GFR), tubular secretion and tubular reabsorption of kidney. GFR depends on the body weight, sex, and creatinine level in the serum. Although the differences between men and women are taken into account by the inclusion of body weight in formulas, but always SKF is higher in women than in men. If one considers a body area, in women GFR on 10-25% is lower. Excretion of drugs, which are allocated without changes in the urine, in women more slowly. For example, digoxin and methotrexate that excreting by the kidneys, according to their clearance in women on 13-17% slower.  Women renal clearance is reduced of such medication as - aminoglycosides, cephalosporins, fluoroquinolones, vancomycin, anticonvulsant ...
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