anesthetic

Choosing a local anesthetic

Choosing a local anesthetic...

The effectiveness of a particular drug is determined by its concentration at the site of administration. It depends on the dose and concentration of the administered solution, its diffusion into tissues and elimination, which in turn is determined by the vasculature in this zone. The latter condition can be changed by the joint use of vasoconstrictors, for example, epinephrine. Toxicity depends on the systemic concentration of the drug formed as a result of its absorption into the blood, or accidental intra-vascular injection. The appointment of vasoconstrictors also reduces these effects. Thus, the correct choice of a local anesthetic plays an important role. Increased lipid solubility Choosing a local anesthetic enhances absorption. Increased ionization, which depends on the drug's pKa ...
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