Pharmacology

Erectile Dysfunction: What is Viagra?

Erectile Dysfunction: What is Viagra?...

Viagra is a medicine for treatment of erectile dysfunction. It affects natural erection mechanism helping a male to get erection. It can be used my men suffering from erectile dysfunction of different kinds (vascular, nervous erection disorder). Formula and product form: Viagra pills 1 or 4 pieces in blister. 1 Viagra pill consists of 25, 50 or 100 mg of sildenafil (sildenafil citrate). Viagra – note to patients: What is Viagra? Viagra is a first drug that is proved to be effective for majority of patients suffering from erectile dysfunction. Viagra helps to receive natural body response to sexual stimulation. Mechanism of Viagra The function of Viagra is to increase blood flow into penis, which helps to achieve natural erection. Viagra affects solely to natural erectile ...
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Influence of gender differences in the activity of medicines.

Influence of gender differences in the activity of medicines....

The excretion of drugs is depending of three factors: the glomerular filtration rate (GFR), tubular secretion and tubular reabsorption of kidney. GFR depends on the body weight, sex, and creatinine level in the serum. Although the differences between men and women are taken into account by the inclusion of body weight in formulas, but always SKF is higher in women than in men. If one considers a body area, in women GFR on 10-25% is lower. Excretion of drugs, which are allocated without changes in the urine, in women more slowly. For example, digoxin and methotrexate that excreting by the kidneys, according to their clearance in women on 13-17% slower.  Women renal clearance is reduced of such medication as - aminoglycosides, cephalosporins, fluoroquinolones, vancomycin, anticonvulsant ...
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