Genetics

Scientific background of siDNA

Scientific background of siDNA...

Cancer treatment mainly consists of surgery wherever possible, chemotherapy and radiotherapy. Combined radio- and chemotherapies can increase the likelihood of success but are limited by their cumulative side effects. Molecular therapies for cancer treatment have emerged in the last decade, such as: monoclonal antibodies targeting the cell membrane receptors, inhibitors of tyrosine kinase receptor or other kinases involved in signal transduction involved in cell proliferation, pro-apoptotic and immunostimulating agents, etc. As cytostatic agents, their monotherapy regimen is rarely of sufficient clinical benefit. Synergistic outcomes are often obtained by their combination with chemo- or radiotherapy. Most traditional cancer treatments are cytotoxic, and directly or indirectly cause ...
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The genesis of the siDNA concept

The genesis of the siDNA concept...

The genesis of the siDNA (signal interfering DNA) concept and its successful demonstration are examples of fruitful translational research where clinicians and scientists shared their viewpoints on clinical bottlenecks and combined their imaginations, intelligences and efforts in moving forward innovative therapeutic solutions against treatment-resistant cancer. The story began in June 2001, when Jean-Marc Cosset, head of the Department of radio-oncology at the Institut Curie talked about the problem of radioresistance in the treatment of head-and-neck cancer to his colleague, Marie Dutreix, a radiobiologist and specialist of genomic instability and DNA repair. Marie Dutreix thought that such radio-resistance arose from high DNA repair capacity of tumor cells to ...
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Modern ideas about the structure of the gene

Modern ideas about the structure of the gene...

Modern ideas about the structure of the gene. The gene carries encrypted hereditary information that determines the leading characteristics of the individual's vital activity and development at all stages of it, beginning with the ebrolic one. The achievements of modern genetics have made it possible to approach the understanding of the chemical and chemical-physical structure of the gene. The genetic specificity of organisms is determined by deoxyribonucleic acid (DNA). Having an extremely complex structure, the DNA molecule consists of purine (adenine, guanine), pyrimidine (cytosine, thymine) bases, 2-deoxyribose and phosphoric acid. Some people are surprised that the initial causal view, being very insignificant at the initial stage of the ontopsychological study, after, likening ...
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